TP53 and lung cancer: Cancers associated with mutations in p53 include a majority of non-melanoma skin cancers, secondary glioblastoma associated with prior chemotherapy, other chemotherapy-induced malignancies (secondary leukemias, etc.), triple-negative breast carcinoma,25, 26 subsets of gastrointestinal malignancies, and subtypes of lung cancers, among others.27 Our research and others’ posit that different mutational stimuli are associated with differing mutational profiles.