We have hypothesized that the glycolytic cell gains a growth advantage in a hostile environment by activating NFκB.40 Indeed, most cells which exhibit aerobic glycolysis demonstrate NFκB activation, which prevents apoptosis in the hypoxic and acidotic tumor environment, and promotes resistance to chemotherapy and radiation, in part through upregulation of chemotherapy efflux pumps such as MDR. Here, NFKB1 is linked to neoplasm.