Cancers associated with mutations in p53 include a majority of non-melanoma skin cancers, secondary glioblastoma associated with prior chemotherapy, other chemotherapy-induced malignancies (secondary leukemias, etc.), triple-negative breast carcinoma,25, 26 subsets of gastrointestinal malignancies, and subtypes of lung cancers, among others.27 Our research and others’ posit that different mutational stimuli are associated with differing mutational profiles. This evidence concerns the gene TP53 and cancer.