TP53 and cancer: Among the tumors associated with loss of p16in4a and wild-type p53 are melanoma, primary glioblastoma, mesothelioma, ER/PR20 and her2/neu-positive breast carcinoma,21 bladder cancer associated with Schistosomiasis, some alcohol, and tobacco-associated head and neck cancers, some lung cancers, and inflammation-induced colon cancer,22 and virtually all cancers induced by Epstein–Barr virus (EBV) (Burkitt’s lymphoma, Hodgkins disease, gastric carcinoma, etc.)and hepatitis C virus (hepatocellular carcinoma), among others.8, 23, 24