THPO and liver disorder: The liver also synthesizes some components of the fibrinolytic system and is responsible for their clearance, consequently some studies have shown a hyperfibrinolytic state in liver disease.51, 52, 53, 54, 55Furthermore, the production of thrombopoietin, which stimulates the production of megakaryocytes (the bone marrow precursor to platelets), is impaired and thus contributes to thrombocytopenia, as does platelet sequestration within the enlarged spleen due to portal hypertension.