Other family members such as TL1A (TNF-like protein 1 A, TNFSF15) (40), FasL (TNFSF6) (41), LIGHT (lymphotoxin-like inducible protein that competes with glycoprotein D for binding herpes virus entry mediator on T cell, TNFSF14) (42), TRAIL (TNF-related apoptosis-inducing ligand, TNFSF10) (43), and TWEAK (TNF-like weak inducer of apoptosis, TNFSF12) (44) also contribute to the pathogenesis of IBD not only by enhancing pro-inflammatory function of T cells in the intestinal mucosa but also by directly disrupting the integrity of intestinal epithelium (45, 46). This evidence concerns the gene TNFSF10 and inflammatory bowel disease.