TJP1 and acute respiratory distress syndrome: Given the role of GSK-3beta in regulating dynamics of MT and in regulating junctional proteins, we examined whether GSK-3beta-dependent activation of GEF-H1/ROCK signaling promotes the disruption of beta-catenin and ZO-1 in lung vascular endothelial cell monolayers in vitro as well as increases lung vascular leak and ALI in vivo under septic conditions.