However, even though our study and other studies (Baumgart et al., 2016; Liu et al., 2016) find that there are various conditions in which the possible involvement of GSK-3beta has been implied (pro-inflammation, hyper-coagulation and hyper-permeability), the efficacy of GSK-3beta inhibitor in inhibiting sepsis-associated ALI in humans has not yet been examined successfully, and further investigations are necessary. This evidence concerns the gene GSK3B and Sepsis.