Likewise, when Broniscer et al. analyzed 32 pediatric and adolescent patients with types I and II GC, their DNA methylation profile corresponded with known pediatric glioma molecular subgroups, including IDH mutant (17%), G34 (22%), mesenchymal (17%), and RTK I “PDGFRA” (44%) (13). The gene discussed is IDH1; the disease is central nervous system cancer.