The importance of VDAC1 in cell energy and metabolism homeostasis is reflected in the findings that closure of VDAC1 (73), or downregulation of VDAC1 expression decreased metabolite exchange between mitochondria and the cytosol and inhibited cell growth (53, 75) [see Silencing VDAC1 Expression by Short Hairpin RNA (shRNA) or siRNA as a Tool to Reprogram Cancer Cell Metabolism]. This evidence concerns the gene VDAC1 and cancer.