VDAC1 and neoplasm: Recently (270), we demonstrated that depleting VDAC1 by si-hVDAC1 assaults critical functional nodes in the oncogenic network of GBM tumors, leading to a multi-pronged attack on cancer hallmarks, reversing cancer-reprogrammed metabolism, thereby inhibiting cell proliferation, tumor growth, EMT, and angiogenesis, and also targets GSCs, leading to their differentiation into neuronal-like cells.