Other important aspect regarding CD8+ T cells response during HIV infection is the memory differentiation pattern; in infected patients, the most frequent subset is the pre-terminally differentiated CD45RA−CCR7− cells, followed by CD45RA+CCR7+ cells, whereas the terminally differentiated CD45RA−CCR7+ cells are found in a lower frequency (74). The gene discussed is CD8A; the disease is HIV infectious disease.