The slower impact of the DNac mutant on Brucella could be due to the fact that it induces IFNγ less rapidly in spleen as demonstrated by the reduced frequency of IFNγ-producing cells in the spleen of DNac T. brucei-infected mice early in co-infection compared to wild-type T. brucei-infected mice (Figures 7C,D). Here, IFNG is linked to coinfection.