IFNAR1 and hyperinsulinemic hypoglycemia, familial, 4: In support of this latter view, herein, reduced APAP toxicity connected to IFNAR deficiency which was observed by analysis of serum ALT (Figure 6A) and histological software-aided evaluation 24 h after administration of 500 mg/kg APAP (29.6 ± 5.3% reduction of liver necrosis in IFNAR-deficient versus wt mice; n = 9, P < 0.01 by unpaired Student’s t-test).