Elevated expression of Tim-3 has been shown to induce lymphocyte exhaustion, and anti-Tim-3 treatment inhibited the splenomegaly induced by PbANKA infection, while elevated the activity of lymphocytes, thus resulted in accelerated clearance of the parasites, reduced neurological signs associated with experimental cerebral malaria and prolonged survival time of PbANKA-infected mice (Hou et al., 2016). This evidence concerns the gene HAVCR2 and Splenomegaly.