GNRH1 and endometrial cancer: We demonstrated that such a cytotoxic GnRH agonist, Zoptarelin Doxorubicin (AEZS-108, AN-152), in which doxorubicin is covalently coupled to the GnRH analog [D-Lys6]GnRH, is selectively accumulated in the nucleus of human GnRH receptor-positive breast, ovarian, and endometrial cancer cell lines.