BDNF and obesity due to melanocortin 4 receptor deficiency: This may also explain as to why exercise is such a potent regulator of obesity and type 2 DM since, regular and adequate exercise enhances production of BDNF and lipoxinA4 (101, 104, 263, 358, 389), two potent anti-obesity and antidiabetic endogenous molecules and regulators of inflammation.