For instance, peroxisome proliferator-activated receptor-γ (PPAR-γ) activators: conjugated linoleic acid (CLA) and troglitazone (12) inhibit free radical generation and TNF-α and IL-2 and, thus, inhibit the occurrence of diabetes in the Zucker diabetic fatty fa/fa rat (13, 14). Here, TNF is linked to diabetes mellitus.