INS and pancreatic insulinoma: In a series of previous studies, we showed that oral feeding of oils rich in ω-3 EPA and DHA and ω-6 GLA and AA or pure FFAs (GLA, AA, EPA, and DHA) prevent apoptosis of insulin-secreting rat insulinoma (RIN5F) cells in vitro and alloxan-induced type 1 DM and STZ-induced type 1 and type 2 DM in experimental animals (15–18, 137, 420).