Thus, presence of abdominal obesity is a physical sign of elevated levels of TNF-α, IL-6, lipids peroxides (since these cytokines stimulate free radical generation), LDL, oxidized LDL, hyperleptinemia, hypertriglyceridemia, and resistin; and low levels of HDL, eNO, adiponectin, IL-4, IL-10, and insulin resistance; hyperinsulinemia and glucose intolerance. The gene discussed is RETN; the disease is Insulin resistance.