LBX1 and lung carcinoma: In lung cancers, about 20–25 HOX genes are expressed at least two-fold higher than normal tissues (Tiberio et al., 1994; Calvo et al., 2000; Plowright et al., 2009), especially, homeobox gene HOXD3 upregulation induced coordinate expression of metastasis-related genes in human lung cancer cells (Hamada et al., 2001), these results indicated that HOX genes could provide new targets for future tumor therapies.