With the observed clinical data that HOXC10 overexpresses in lung cancer tissues, especially in tissues with metastatic potential, and predicts a poor prognosis of lung cancer patients from our local hospital, GEO dataset, and Kaplan-Meier plotter database, our study may thus provide useful information for the development of HOX gene-targeted therapy or prognostic biomarker development. This evidence concerns the gene HOXC10 and lung cancer.