Therefore, we chose H1975 and H460 cells to explore the role of HOXC10 in lung cancer metastasis, mainly through interfering HOXC10 expression in H1975 cells with HOXC10 shRNA and overexpressing HOXC10 expression with pcDNA3.1-HOXC10 recombinant plasmid in H460 cells. The gene discussed is HOXC10; the disease is lung carcinoma.