In lung cancers, about 20–25 HOX genes are expressed at least two-fold higher than normal tissues (Tiberio et al., 1994; Calvo et al., 2000; Plowright et al., 2009), especially, homeobox gene HOXD3 upregulation induced coordinate expression of metastasis-related genes in human lung cancer cells (Hamada et al., 2001), these results indicated that HOX genes could provide new targets for future tumor therapies. This evidence concerns the gene HOXD3 and lung cancer.