SPP1 and hypertensive disorder: Instead, activation of the sympathetic nervous system or RAAS that is caused by running and hypertension induces via Ang-II the expression of OPN and subsequently of LOX which specifically activates the Col-III promoter and increases the rigidity of the ventricle due to cross-linking (Matsui et al., 2004; Nakayama et al., 2011; Lorenzen et al., 2015).