COPS8 and gastric cancer: In gastric cancer, in addition to its role in TLR/IL-1R signaling, miR-146a-5p has been reported to directly control the G-protein-coupled receptor-mediated activation of NF-κB, via caspase recruitment domain-containing protein 10 (CARD10) and COP9 signalosome complex subunit 8 (COPS8) (Crone et al., 2012).