Evidence produced from Dicer-knockout in-vivo experiments demonstrate that adipose specific Dicer-knockouts exhibit a phenotype that resembles humans with partial lipodystrophy (atrophy of WAT), hypertrophy and “whitening” of BAT, insulin resistance, dyslipidemia, impaired resistance to oxidative stress and premature aging (Mori et al., 2014; Reis et al., 2016). This evidence concerns the gene DICER1 and metabolic syndrome.