NOS2 and Insulin resistance: We reported that prolonged inhibition of iNOS with 1,400 W (Haddad and Couture, 2016) blunted the production of peroxynitrite in the model of insulin resistance, suggesting that this oxidative pathway contributes to the upregulation of the biomarkers of inflammation (iNOS, CPM, B1R, and IL-1β) and represents an important mechanism leading to insulin resistance.