This study reinforces the detrimental role for kinin B1R in insulin resistance because the inhibition of the main enzymes (CPM/CPN) involved in the biosynthesis of the endogenous B1R agonists (des-Arg9-BK and Lys-des-Arg9-BK) improved hyperglycemia, hyperinsulinemia and the HOMA index of insulin resistance. Here, BDKRB1 is linked to Insulin resistance.