Therefore, the impact of a 1-week pharmacological treatment with Mergetpa was determined on insulin resistance, metabolic hormones levels, hypertension, vascular and non-vascular inflammatory markers (iNOS, B1R, CPM, IL-1β) and oxidative stress (O2•− and ONOO−) in the model of insulin resistance induced by high glucose feeding. This evidence concerns the gene NOS2 and hypertensive disorder.