Nevertheless, our data highlight a dissociation regarding the mechanisms underlying insulin resistance and hypertension as previously evidenced with the iNOS inhibitor (Haddad and Couture, 2016), and support the idea that peripheral B1R do not contribute to hypertension as reported in other rat models (De Brito Gariépy et al., 2010; Couture et al., 2014). This evidence concerns the gene NOS2 and Insulin resistance.