DCN and obesity due to melanocortin 4 receptor deficiency: In 3T3-L1 adipocytes, we evaluated the effect of organotins on the expression of inflammatory response-related genes such as Lgals9, Fn1, Dcn, Vcam1 and S100a8, which are accordingly related to obesity and insulin resistance (Andersen et al., 1987; Osborn et al., 1989; Daquinag et al., 2011; Xue et al., 2011; Sekimoto et al., 2012; Kurose et al., 2013).