For example, in B-cell chronic lymphocytic leukemia (B-CLL), the camptothecin analog, 9-amino-20(s)-camptothecin, and the purine analog, fludarabine, resulted in the cleavage of Bax p21 to p18, producing a greater magnitude of apoptosis (Thomas et al., 1996). Here, BAX is linked to B-cell chronic lymphocytic leukemia.