Th2 cells can induce B cell response to produce IgE and consequently activate mastocytes and eosinophils and regulate pro-inflammatory response, whereas Th1 cells directly or indirectly, inhibit inflammatory activities by preventing the Th2 response and thus, regulate the inflammatory responses of mast cells and eosinophils which are the main player cells in allergic asthma. The gene discussed is IGHE; the disease is allergic asthma.