ABCA1 and Alzheimer disease: Moreover, the K allele of the R219K polymorphism in ABCA1 gene is associated with the increased plasma HDL-c and decreased TG levels (Clee et al., 2001; Miller et al., 2003), which might be related with the late-onset AD (Kehoe et al., 1999; Burns et al., 2006; Donkin et al., 2010).