Moreover, stress is known to be associated with tinnitus (e.g., Hébert et al., 2004; Hébert and Lupien, 2007, 2009; Alsalman et al., 2016) and stress-related hormones like cortisol and adrenocorticotropic hormone (ACTH) underlie circadian rhythms (e.g., Dickmeis, 2009; Lightman and Conway-Campbell, 2010; Conway-Campbell et al., 2012), which could influence the potential time-of-day-dependence of tinnitus (loudness and distress). The gene discussed is POMC; the disease is Tinnitus.