Our meta-analysis on studies that evaluated the presence of aCL in patients with VD (n = 472) (Lopez et al., 1992; Juby and Davis, 1998; Mosek et al., 2000; Tan et al., 2001; de Godoy et al., 2005; Zeng et al., 2006; Qian et al., 2015) indicated that aCL was significantly present in VD patients as compared to healthy controls (OR: 6.89, 95% CI: 3.73–12.74, p < 0.00001; I2 = 0%, p = 0.41) (Figure 3A). The gene discussed is ACLY; the disease is sexually transmitted disease.