APOE and Mental deterioration: Prada and colleagues reported a rather protective effect of only ApoE rs429358 variant on cognitive function (Prada et al., 2014); however, in our study, no association between ApoE rs7412 polymorphism with cognitive function was observed in the elderly which is rather suggestive that carriers of ApoE rs429358 variant are more susceptible to cognitive decline while on the contrary, carriers of ApoE rs7412 variant apparently seem to express a stronger resistance to cognitive decline compared to ApoE rs429358 variants in these aging Chinese population.