Mutated huntingtin impairs the function of cAMP response element-binding protein (CREB; Steffan et al., 2000; Sugars and Rubinsztein, 2003; Sugars et al., 2004), suggesting that inhibition of CREB-mediated gene transcription could play an important role in HD (Kazantsev et al., 1999; Steffan et al., 2000; Nucifora et al., 2001; Mantamadiotis et al., 2002; Jiang et al., 2003). The gene discussed is HTT; the disease is Huntington disease.