However, DRGs of mGFAP-Cre;Smarcb1flox/flox;Nf2flox/flox mice showed a significantly increased cellularity compared to those of mGFAP-Cre;Smarcb1flox/flox;Nf2flox/+ mice (0.0044 vs. 0.0028 cells/μm2, P = 0.0008) (Fig. 5d, e, g), thus demonstrating the crucial and necessary role of biallelic Nf2 loss for schwannoma formation. The gene discussed is NF2; the disease is schwannoma.