Analysis of molecular pathways in P0-CreC;Smarcb1flox/flox RTs by western blot showed increased phosphorylation of Akt, S6, and 4E-BP1, consistent with activation of the mTOR/Akt pathway, similar to schwannomas in P0-CreC;Nf2flox/flox mice (Supplementary Fig. 4c). This evidence concerns the gene AKT1 and schwannoma.