NF2 and neoplasm: The observation of frequent somatic, tumor-specific NF2 mutations, and the loss of the second NF2 allele in schwannomas from patients with germline SMARCB1 mutations10, 57–59 strongly suggest that the classical two-hit model of tumorigenesis does not pertain in the tumors of schwannomatosis patients, as it would require biallelic SMARCB1 inactivation to be sufficient for tumor initiation or growth7.