LOXL4 and hepatocellular carcinoma: HDGFRP3 (Hepatoma-Derived Growth Factor, Related Protein 3), which plays an essential role in hepatocellular carcinoma pathogenesis46 and LOXL4 (Lysyl Oxidase Like 4), which promotes proliferation and metastasis of gastric cancer47, were consistently overexpressed in mouse and human SHH and MYC molecular subgroups, respectively (Fig. 4c).