Conditional Smarcb1 inactivation in all tissues except the brain led to 100% of mice developing T-cell lymphoma with 13% of mice developing RTs with a median latency of 11 weeks after induction, demonstrating that inactivation of the second Smarcb1 allele is rate limiting RT development in Smarcb1+/− mice35. Here, SMARCB1 is linked to T-cell non-Hodgkin lymphoma.