In the KEGG pathway analysis, the top pathways upregulated in H1152-treated INS-GFP+ cells are insulin secretion and type 2 diabetes mellitus, which include the key genes involved in pancreatic differentiation, including KCNJ11, ABCC8, GCK, INS, PDX1, SLC2A2, CACNA1A, CACNA1D, and GLP1R (Fig. 3b and c). Here, PDX1 is linked to diabetes mellitus.