CACNA1D and type 2 diabetes mellitus: In the KEGG pathway analysis, the top pathways upregulated in H1152-treated INS-GFP+ cells are insulin secretion and type 2 diabetes mellitus, which include the key genes involved in pancreatic differentiation, including KCNJ11, ABCC8, GCK, INS, PDX1, SLC2A2, CACNA1A, CACNA1D, and GLP1R (Fig. 3b and c).