CSF2 and asthma: Chromosome 5q31–36 contains an asthma susceptibility locus consisting of several genes associated with inflammation, certain cytokines, and the Granulocyte Macrophage Colony-Stimulating Factor-2 (GM-CSF2).8, 25 Expression of the Ugrp2 gene is downregulated in nasal polyposis through the differentiation of human upper airway epithelial cells, suggesting that this gene has a role in the differentiation of mucinous epithelial cells such as adenoid tissues.8, 26