SCGB3A1 and allergic disease: UGRP2 is a small secretory protein that is highly expressed in airway epithelial tissues.8, 9, 10 The expression of UGRP2 is associated with cytokines and proinflammatory cytokines that play a critical role in AH.5, 6, 26 Our results suggest that some SNPs and combinations of SNPs may affect the expression of Ugrp2, inducing changes in cytokine expression leading to a local immune response and upper airway inflammation; this increases the risk of asthma and allergic reactions in children with AH.