The Ugrp2 (Scgb3a1) gene was reported to play a role in the pathogenesis of some cancers, as well as upper and lower airway inflammatory diseases including asthma, allergies, and nasal polyposis.8, 9, 10 It was also reported that UGRP2 is a potent inhibitor of cell growth, migration, and invasion via the AKT signaling pathway.9 This evidence concerns the gene SCGB3A1 and allergic disease.