APP and Alzheimer disease: Recently, using early-onset familial Alzheimer’s (fAD) patient-derived iPSCs with APP duplication, Raja et al. recapitulated Alzheimer’s disease phenotypes including β-amyloid (Aβ) aggregation, hyperphosphorylated Tau (pTau), and endosome abnormalities in fAD patient-derived 3D brain organoids [93].