This study is focusing on VDR ApaI rs7975232 (G > T) variant, BsmI rs1544410 (A > G) variant, Taq1rs731236 (T > C) variant and FokIrs2228570 (C > T) variant and Insulin resistance related diseases susceptibility including (T2DM, MetS and PCOS). Here, VDR is linked to metabolic syndrome.