The present observations in Pgc-1β−/− hearts parallel features reported in Scn5a+/− and RyR2-P2328S/P2328S cardiac models for Brugada syndrome and catecholaminergic polymorphic ventricular tachycardia, respectively [33–35, 39]. The gene discussed is RYR2; the disease is catecholaminergic polymorphic ventricular tachycardia.