This difference in gene expression points at a possible key role for TFs in the modulation of the phenotypic behavior of glioma cells, especially considering that numerous TFs (e.g., ZEB1, STAT3, C/EBPb, and TAZ) have been shown to play a critical role in the induction of invasive mesenchymal phenotypes in GBM cells [68, 93, 155]. Here, ZEB1 is linked to glioblastoma.