ZEB1 and central nervous system cancer: Accordingly, active Wnt/β-catenin signaling in primary GBM-derived cultures induced the expression of key EMT activators, including ZEB1, TWIST1, SLUG1, and enhanced the migratory capacity of the cells in vitro, whereas silencing β-catenin through RNA-interference decreased the expression of these EMT-related TFs and abrogated glioma cell invasion [178].