Considering that Dlx5 regulates Wnt5a expression during CNS development [75] and has been found to be expressed in GSCs [76], it appears that GSCs hijack this developmentally regulated Pax6/Dlx5-Wnt5A transcriptional axis to drive the differentiation of GSCs into endothelial-like cells, thus promoting the diffuse spread of infiltrative GBM cells. The gene discussed is DLX5; the disease is glioblastoma.