The top significantly enriched pathways in AD and psoriasis included Cytokine–Cytokine-Receptor Interaction, Chemokine–Chemokine-Receptor Binding, Chemokine Signaling, Cytokine Network, Jak-STAT Signaling, Toll-like Receptor Signaling, and IL-23 Signaling. This evidence concerns the gene IL18R1 and Alzheimer disease.