CD4 and myeloid sarcoma: In addition, this significant decrease in global methylation levels could be related both to an increase in the percentage of Treg cells (CD4+CD25+FoxP3+) and to the restoration of the suppressive function of these cells, described in MS patients treated with IFNβ49, since Mangano et al. also reported both an increase in the percentage of Treg cells and a restoration of their function in an EAE model after treatment with the hypomethylating agent (5-aza-2′-deoxycytidine), by inducing Foxp3 expression via demethylation of a CpG island in Foxp322.