iv.Expression of either ligand or receptor is decreased in cancer but not both (Table S4), such as CNTFR, LIFR, SSTR1, CXCL12, NPY1R, RELN, RSPO3, TGFBR3 etc. CNTFR involves with neuronal cell survival and differentiation; LIFR involves cellular differentiation and proliferation. The gene discussed is TGFBR3; the disease is cancer.