In contrast, hyper-methylation identified within the TSS1500 of Nescient helix-loop-helix 2 (NHLH2), Phospholipase C eta 1 (PLCH1), Transmembrane protein 132B (TMEM132B), and WD repeat domain 81 (WDR81) correlated with the decrease in mRNA levels of these genes following demyelination in MS hippocampus. This evidence concerns the gene NHLH2 and myeloid sarcoma.