Immunohistochemical analysis showed that DNMT1 (Fig. 1B,C), DNMT3A (Fig. 1D,E) and DNMT3B (Fig. 1F,G) were primarily associated with hippocampal neurons in MS myelinated (Fig. 1B,D,F) and MS demyelinated (Fig. 1C,E,G) hippocampus. Here, DNMT1 is linked to myeloid sarcoma.