Immunohistochemical analysis to confirm cellular localization, showed that SFRP1 (Fig. 4B,C), and PLCH1 (Fig. 4D,E) were primarily associated with hippocampal neurons in MS myelinated (Fig. 4B,D) and MS demyelinated (Fig. 4C,E) hippocampus. The gene discussed is SFRP1; the disease is myeloid sarcoma.