Plasma lysoPCs were negatively associated with BMI and plasma insulin concentrations, but had no relationship with glucose and the homeostatic model assessment-insulin resistance, which suggests that adiposity underlies the observed changes rather than insulin resistance or T2DM (5); however, in the current study, lysoPC responses seem to be more consistent—lysoPCs with significant group differences had lower levels in the OW/OB group that were lower still in T2DM, which suggests that they are affected by both weight and T2DM. The gene discussed is INS; the disease is Insulin resistance.