The physiopathological implications of our studies show that human colonic polyps not only have significantly reduced Jak3 expression and localization compared with healthy mucosal counterparts but that these polyps also have a significantly elevated level of the EMT marker N-cadherin, indicating that robust Jak3 expression is required for the suppression of EMT and associated colonic polyp formation. The gene discussed is JAK3; the disease is polyp of colon.