SNCA and Parkinson disease: Our goals were to identify the variability in potential candidate biomarkers of inflammation to power larger studies and generate hypotheses, to examine relationships between CSF and serum inflammation for each inflammatory factor, to examine associations between peripheral and central inflammatory factors and CSF levels of α-synuclein, β-amyloid 1–40 (Aβ40), and 1–42 (Aβ42), and to define an ideal set of inflammatory factors in serum and CSF to be used in conjunction with levels of CSF α-synuclein and Aβ proteins to distinguish PD vs HC subjects with sensitivity and specificity.