IFNG and Parkinson disease: When UPDRS component scores were examined separately, CSF IFNγ levels increased as the activities of daily living (ADL) score (Fig. 4b) and the complication of therapy score (Fig. 4c) increased, indicating that the highest levels of CSF IFNγ are found in PD subjects with the most disruption of daily living activities and the most complication experienced due to therapeutic treatment.