PANK2 and pantothenate kinase-associated neurodegeneration: It is worth noting that in individuals with PKAN, Magnetic Resonance Imaging (MRI) is characterized by “eye-of-the-tiger” sign, T2-hypointensity of the globus pallidus with a central hyperintensity, corresponding to excessive brain iron accumulation [22] and predicting a disease causing mutation in PANK2 gene [23].