In summary, we recommend, that for patients with a pre-operative cTn <1× URL, isolated elevations of ‘standard’ cTn assays (cTnT ≥7× URL and cTnI ≥20× URL) within the 48 h post-operative period (in the absence of ECG/angiographic or other imaging evidence of MI), may be indicative of prognostically significant PMI, and require further clinical evaluation to determine whether there is evidence for Type 5 MI. This evidence concerns the gene TNNT2 and myocardial infarction.