MYC and hemoglobin measurement: In the current work, we utilized two mouse models of liver cancer in which the over-expression of mutant forms of β-catenin and yes-associated protein [11] or the oncoprotein c-Myc (Myc), recapitulate pediatric hepatoblastoma (HB) [12] or hepatocellular carcinoma (HCC), respectively [13, 14].