IFNAR2 and Zika virus infectious disease: In other models for ZIKV challenge in which peripheral challenge of virus has been assessed through subcutaneous,8 i.p.,8 intravenous,11 or intrauterine/intravaginal routes,16,17 immunocompetent mice were not highly susceptible to establishing ZIKV infections or demonstrating significant disease; thus, previously reported mouse models for ZIKV pathogenesis have largely used immunodeficient mice,8,9,15,18,19 immunocompetent mice treated with antibodies targeting interferon receptors,20–22 or murine-adapted ZIKV strains.21