We further observed that maternal choline supplementation in HF dams decreased expression of other fatty acid synthesizing genes, including Acc1, Elovl5, and Fads1. The additional decrease in de novo lipogenic gene expression in the HFCS versus HFCO fetuses may further diminish fatty acid synthesis, thereby compensating for the increased influx of lipids from the HF dams. The gene discussed is ELOVL5; the disease is hydrops fetalis.