Considering the search criteria: TITLE-ABS-KEY (nutrition OR diet) AND TITLE-ABS-KEY (“metabolic disorder” OR “metabolic alteration” OR obesity OR “metabolic syndrome” OR diabetes OR “cardiovascular disease” OR cholesterol OR insulin OR atherosclerosis OR inflammation OR “oxidative stress”), around 272,000 were found. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.