Lungs of Ogg1 null mice were strongly affected by DMBDD initiation, which could be concluded from significant increases of lung adenocarcinoma incidence in DMBDD-treated Ogg1−/− male mice and incidences and multiplicities of adenomas and total lung tumors in Ogg1−/− males and females. This evidence concerns the gene OGG1 and lung adenocarcinoma.