With respect to the NASH stage, activated Kupffer cell, hepatic inflammation promoters, such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1) gene expression are the important features of the progression from NAFL to NASH [15]. Here, TNF is linked to metabolic dysfunction-associated steatohepatitis.