Assessing the influence of Nrf2 deletion in genetic models of Huntington’s disease would provide further insight into a potential mutant huntingtin-dependent mechanism of Nrf2 impairment, reminiscent of amyotrophic lateral sclerosis, in which Nrf2 deletion has little impact on the survival of disease model mice. This evidence concerns the gene NFE2L2 and amyotrophic lateral sclerosis.