HTT and Huntington disease: Thiazole-containing derivatives of 5-nitro-8-R-quinoline (e.g., MIND4) protect ex vivo rat brain slices transiently transfected with mutant huntingtin and a drosophila model of Huntington’s disease, and activate Nrf2 [219] in a mechanism involving Keap1 Cys-151 modification [84].