However, more recent studies investigating post-mortem Alzheimer’s disease brain tissue found an increase in Nrf2 and p62 in cells expressing high levels of amyloid precursor protein or neurofibrillary tangles, and other Nrf2 targets are also elevated [9,100], as are Nrf2 target gene transcripts [37]. The gene discussed is NFE2L2; the disease is early-onset autosomal dominant Alzheimer disease.