As in Alzheimer’s disease, although expression of Keap1 is unchanged [153], Keap1 is found associated with intracellular inclusions in spinal cord motor neurons [37], and Keap1 mRNA is elevated in the motor cortex of post-mortem amyotrophic lateral sclerosis brain [153]. This evidence concerns the gene KEAP1 and early-onset autosomal dominant Alzheimer disease.