Other pharmacological inducers of Nrf2 have shown protective effects in the experimental autoimmune encephalomyelitis model of multiple sclerosis, including the triterpenoid CDDO-trifluoroethylamide (also effective in the lysophosphatidyl choline model) [234], 3H-1,2-dithiole-3-thione [243], sulforaphane [230], the natural alkaloid matrine [244] and TFM-735, which was identified from a chemical library screen [245] (Table 7). This evidence concerns the gene NFE2L2 and multiple sclerosis.