Supporting increased Nrf2 activity in Alzheimer’s disease, further analysis of Nrf2 targets in post-mortem Alzheimer’s disease brain shows increased NQO1 expression in hippocampus [104,105] and frontal cortex (although less strongly than in hippocampus) [109], while HO1 is increased in temporal cortex and hippocampus of Alzheimer’s disease brains [9,100,101,102,103]. Here, NQO1 is linked to early-onset autosomal dominant Alzheimer disease.