AHSG and hepatocellular carcinoma: An example of HCC-specific 5hmC enriched genes is AHSG, a secreted protein highly expressed in the liver24 (Figure 3C; Supplementary information, Figure S5B and S5C), and an example of HCC-specific 5hmC depleted genes is TET2, one of the enzymes that generate 5hmC and a tumor suppressor down-regulated in HCC27 (Figure 3D; Supplementary information, Figure S5D).