These particular molecular mass and glycoform profile characteristics seem to be a hallmark of vCJD transmission to human-PrP Val129, since these features were also found in a different human-PrP Val129 transgenic mouse line challenged with vCJD (vCJD→Ki-Hu129V/V) (26) (Figure 3, lane 8). The gene discussed is PRNP; the disease is variant Creutzfeldt-Jakob disease.